Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging.

ABSTRACT: During aging and neuromuscular diseases, there is a progressive loss of skeletal muscle volume and function impacting mobility and quality of life. Muscle loss is often associated with denervation and a loss of resident muscle stem cells (satellite cells or MuSCs); however, the relationship between MuSCs and innervation has not been established. Herein, we administered severe neuromuscular trauma to a transgenic murine model that permits MuSC lineage tracing. We show that a subset of MuSCs specifically engraft in a position proximal to the neuromuscular junction (NMJ), the synapse between myofibers and motor neurons, in healthy young adult muscles. In aging and in a mouse model of neuromuscular degeneration (Cu/Zn superoxide dismutase knockout - Sod1^-/-), this localized e

SUBMITTER: Larouche JA 

PROVIDER: S-EPMC8360658 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature