Predominantly linear summation of metabotropic postsynaptic potentials follows coactivation of neurogliaform interneurons.

ABSTRACT: Summation of ionotropic receptor-mediated responses is critical in neuronal computation by shaping input-output characteristics of neurons. However, arithmetics of summation for metabotropic signals are not known. We characterized the combined ionotropic and metabotropic output of neocortical neurogliaform cells (NGFCs) using electrophysiological and anatomical methods in the rat cerebral cortex. These experiments revealed that GABA receptors are activated outside release sites and confirmed coactivation of putative NGFCs in superficial cortical layers in vivo. Triple recordings from presynaptic NGFCs converging to a postsynaptic neuron revealed sublinear summation of ionotropic GABAA responses and linear summation of metabotropic GABAB responses. Based on a model combining properties of v

SUBMITTER: Ozsvar A 

PROVIDER: S-EPMC8360660 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature