Data Mining, Network Pharmacology, and Molecular Docking Explore the Effects of Core Traditional Chinese Medicine Prescriptions in Patients with Rectal Cancer and Qi and Blood Deficiency Syndrome.

ABSTRACT:

Background

"Zheng" (syndrome) is the basic unit and the basis of traditional Chinese medicine (TCM) treatment. In clinical practice, we have been able to improve the survival time and quality of life for patients with rectal cancer through the treatment of "FuZhengXiaoJi" (strengthening the Qi and reducing accumulation).

Purpose

In this study, we elucidated the core prescriptions for patients with rectal cancer and Qi and blood deficiency syndrome, and we explored the potential mechanisms of the prescriptions using an integrated strategy that coupled data mining with network pharmacology.

Methods

A Bron-Kerbosch (BK) algorithm was applied to find the core prescriptions. The active ingredients, targets, activated signaling pathways, and biological functions of core pre

SUBMITTER: Ma S 

PROVIDER: S-EPMC8360715 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature