A targeted multi-omics approach reveals paraoxonase-1 as a determinant of obesity-associated fatty liver disease.

ABSTRACT:

Background

The multifactorial nature of non-alcoholic fatty liver disease cannot be explained solely by genetic factors. Recent evidence revealed that DNA methylation changes take place at proximal promoters within susceptibility genes. This emphasizes the need for integrating multiple data types to provide a better understanding of the disease's pathogenesis. One such candidate gene is paraoxonase-1 (PON1). Substantial interindividual differences in PON1 are apparent and could influence disease risk later in life. The aim of this study was therefore to determine the different regulatory aspects of PON1 variability and to examine them in relation to the predisposition to obesity-associated fatty liver disease.

Results

A targeted multi-omics approach was applied to investigat

SUBMITTER: Diels S 

PROVIDER: S-EPMC8360816 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature