Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Y
PROVIDER: S-EPMC8360840 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Zhou Yanjun Y Heitmann Jonas S JS Clar Kim L KL Kropp Korbinian N KN Hinterleitner Martina M Engler Tobias T Koch André A Hartkopf Andreas D AD Zender Lars L Salih Helmut R HR Maurer Stefanie S Hinterleitner Clemens C
Cancer immunology, immunotherapy : CII 20210204 9
Owing to their key role in several diseases including cancer, activating and inhibitory immune checkpoint molecules are increasingly exploited as targets for immunotherapy. Recently, we demonstrated that platelets, which largely influence tumor progression and immune evasion, functionally express the ligand of the checkpoint molecule GITR. This immunoreceptor modulates effector functions of T cells and NK cells with its function varying dependent on cellular context and activation state. Here, w ...[more]