Impact of viral features, host jumps and phylogeography on the rapid evolution of Aleutian mink disease virus (AMDV).

ABSTRACT: Aleutian mink disease virus (AMDV) is one the most relevant pathogens of domestic mink, where it can cause significant economic losses, and wild species, which are considered a threat to mink farms. Despite their relevance, many aspects of the origin, evolution, and geographic and host spreading patterns of AMDV have never been investigated on a global scale using a comprehensive biostatistical approach. The present study, benefitting from a large dataset of sequences collected worldwide and several phylodynamic-based approaches, demonstrates the ancient origin of AMDV and its broad, unconstrained circulation from the initial intercontinental spread to the massive among-country circulation, especially within Europe, combined with local persistence and evolution. Clear expansion of the vira

SUBMITTER: Franzo G 

PROVIDER: S-EPMC8360955 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature