Tumor Treating Fields for Ovarian Carcinoma: A Modeling Study.

ABSTRACT:

Purpose

Since the inception of tumor treating fields (TTFields) therapy as a Food and Drug Administration-approved treatment with known clinical efficacy against recurrent and newly diagnosed glioblastoma, various in silico modeling studies have been performed in an effort to better understand the distribution of applied electric fields throughout the human body for various malignancies or metastases.

Methods and materials

Postacquisition attenuation-corrected positron emission tomography-computed tomography image data sets from 2 patients with ovarian carcinoma were used to fully segment various intrapelvic and intra-abdominal gross anatomic structures. A 3-dimensional finite element mesh model was generated and then solved for the distribution of applied electric fields, r

SUBMITTER: Lok E 

PROVIDER: S-EPMC8361065 | biostudies-literature | 2021 Jul-Aug

REPOSITORIES: biostudies-literature