Monoclonal antibodies block transmission of genetically diverse Plasmodium falciparum strains to mosquitoes.

ABSTRACT: Malaria parasite transmission to mosquitoes relies on the uptake of sexual stage parasites during a blood meal and subsequent formation of oocysts on the mosquito midgut wall. Transmission-blocking vaccines (TBVs) and monoclonal antibodies (mAbs) target sexual stage antigens to interrupt human-to-mosquito transmission and may form important tools for malaria elimination. Although most epitopes of these antigens are considered highly conserved, little is known about the impact of natural genetic diversity on the functional activity of transmission-blocking antibodies. Here we measured the efficacy of three mAbs against leading TBV candidates (Pfs48/45, Pfs25 and Pfs230) in transmission assays with parasites from naturally infected donors compared to their efficacy against the strain they we

SUBMITTER: de Jong RM 

PROVIDER: S-EPMC8361195 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature