Knocking down Israa, the Zmiz1 intron-nested gene, unveils interrelated T cell activation functions in mouse.

ABSTRACT: We previously reported Israa (immune-system-released activating agent), a novel gene nested in intron 6 of the mouse Zmiz1 gene. Zmiz1 is involved in several functions such as fertility and T cell development and its knockout leads to non-viable embryos. We also reported ISRAA's expression in lymphoid organs, particularly in the thymus CD³⁺ T cells during all developmental stages. In addition, we showed that ISRAA is a binding partner of Fyn and Elf-1 and regulates the expression of T cell activation-related genes in vitro. In this paper, we report the generation and characterization of an Israa ^-/- constitutive knockout mouse. The histological study shows that Israa ^-/- mice exhibit thymus and

SUBMITTER: Ben Khalaf N 

PROVIDER: S-EPMC8361231 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature