Protective efficacy of the anti-HIV broadly neutralizing antibody PGT121 in the context of semen exposure.

ABSTRACT:

Background

HIV-1 infections occur following viral exposure at anogenital mucosal surfaces in the presence of semen. Semen contains immunosuppressive and pro-inflammatory factors. Semen from HIV-1-infected donors contains anti-HIV-1 antibodies. We assessed if passively infused anti-HIV-1 neutralizing antibody conferred protection from rectal SHIV_SF162P3 challenge at semen exposed mucosae.

Methods

We pooled seminal plasma from HIV-1-infected donors. The pool was screened by ELISA for antibodies against HIV-1_SF162 gp140. The ability of seminal plasma to inhibit macaque NK cells from responding to direct and antibody-dependent stimulation was assessed. The ability of seminal plasma to inhibit macaque granulocytes from mediating oxidative burst was also asse

SUBMITTER: Parsons MS 

PROVIDER: S-EPMC8361295 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature