Placental growth factor in assessment of women with suspected pre-eclampsia to reduce maternal morbidity: a stepped wedge cluster randomised control trial (PARROT Ireland).

ABSTRACT:

Objective

To determine whether the addition of placental growth factor (PlGF) measurement to current clinical assessment of women with suspected pre-eclampsia before 37 weeks' gestation would reduce maternal morbidity without increasing neonatal morbidity.

Design

Stepped wedge cluster randomised control trial from 29 June 2017 to 26 April 2019.

Setting

National multisite trial in seven maternity hospitals throughout the island of Ireland PARTICIPANTS: Women with a singleton pregnancy between 20⁺⁰ to 36⁺⁶ weeks' gestation, with signs or symptoms suggestive of evolving pre-eclampsia. Of the 5718 women screened, 2583 were eligible and 2313 elected to participate.

Intervention

Participants were assigned randomly to either usual care or to usua

SUBMITTER: Hayes-Ryan D 

PROVIDER: S-EPMC8361324 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature