Reproductive Longevity and Aging: Geroscience Approaches to Maintain Long-Term Ovarian Fitness.

ABSTRACT: Increases in delayed childbearing worldwide have elicited the need for a better understanding of the biological underpinnings and implications of age-related infertility. In women 35 years and older the incidences of infertility, aneuploidy, and birth defects dramatically increase. These outcomes are a result of age-related declines in both ovarian reserve and oocyte quality. In addition to waning reproductive function, the decline in estrogen secretion at menopause contributes to multisystem aging and the initiation of frailty. Both reproductive and hormonal ovarian function are limited by the primordial follicle pool, which is established in utero and declines irreversibly until menopause. Because ovarian function is dependent on the primordial follicle pool, an understanding of the mech

SUBMITTER: Llarena N 

PROVIDER: S-EPMC8361335 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature