Frailty Changes Predict Mortality in 4 Longitudinal Studies of Aging.

ABSTRACT:

Background

Baseline frailty index (FI) values have been shown to predict mortality among older adults, but little is known about the effects of changes in FI on mortality.

Methods

In a coordinated approach, we analyzed data from 4 population-based cohorts: the Health and Retirement Study (HRS), the Survey of Health, Ageing and Retirement in Europe (SHARE), the English Longitudinal Survey of Ageing (ELSA), and the Longitudinal Aging Study Amsterdam (LASA), comprising a total of 24 961 respondents (65+), 95 897 observations, up to 9 repeated FI assessments, and up to 23 years of mortality follow-up. The effect of time-varying FI on mortality was modeled with joint regression models for longitudinal and time-to-event data.

Results

Differences (of 0.01) in current FI leve

SUBMITTER: Stolz E 

PROVIDER: S-EPMC8361367 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature