Blood-Based Biomarkers and Long-term Risk of Frailty-Experience From the Swedish AMORIS Cohort.

ABSTRACT:

Background

Frailty is associated with reduced quality of life, poor health outcomes, and death. Past studies have investigated how specific biomarkers are associated with frailty but understanding biomarkers in concert with each other and the associated risk of frailty is critical for clinical application.

Methods

Using a sample aged ≥59 years at baseline from the Swedish AMORIS (Apolipoprotein MOrtality RISk) cohort (n = 19 341), with biomarkers measured at baseline (1985-1996), we conducted latent class analysis with 18 biomarkers and used Cox models to determine the association between class and frailty and all-cause mortality.

Results

Four classes were identified. Compared to the largest class, the Reference class (81.7%), all other classes were associated with in

SUBMITTER: Wennberg AM 

PROVIDER: S-EPMC8361369 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature