Cortical and phase rim lesions on 7 T MRI as markers of multiple sclerosis disease progression.

ABSTRACT: In multiple sclerosis, individual lesion-type patterns on magnetic resonance imaging might be valuable for predicting clinical outcome and monitoring treatment effects. Neuropathological and imaging studies consistently show that cortical lesions contribute to disease progression. The presence of chronic active white matter lesions harbouring a paramagnetic rim on susceptibility-weighted magnetic resonance imaging has also been associated with an aggressive form of multiple sclerosis. It is, however, still uncertain how these two types of lesions relate to each other, or which one plays a greater role in disability progression. In this prospective, longitudinal study in 100 multiple sclerosis patients (74 relapsing-remitting, 26 secondary progressive), we used ultra-high field 7-T suscepti

SUBMITTER: Treaba CA 

PROVIDER: S-EPMC8361394 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature