12-year prediction of mild cognitive impairment aided by Alzheimer's brain signatures at mean age 56.

ABSTRACT: Neuroimaging signatures based on composite scores of cortical thickness and hippocampal volume predict progression from mild cognitive impairment to Alzheimer's disease. However, little is known about the ability of these signatures among cognitively normal adults to predict progression to mild cognitive impairment. Towards that end, a signature sensitive to microstructural changes that may predate macrostructural atrophy should be useful. We hypothesized that: (i) a validated MRI-derived Alzheimer's disease signature based on cortical thickness and hippocampal volume in cognitively normal middle-aged adults would predict progression to mild cognitive impairment; and (ii) a novel grey matter mean diffusivity signature would be a better predictor than the thickness/volume signature. This co

SUBMITTER: Williams ME 

PROVIDER: S-EPMC8361427 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature