Cross-Linking Cellular Prion Protein Induces Neuronal Type 2-Like Hypersensitivity.

ABSTRACT:

Background

Previous reports identified proteins associated with 'apoptosis' following cross-linking PrP^C with motif-specific anti-PrP antibodies in vivo and in vitro. The molecular mechanisms underlying this IgG-mediated neurotoxicity and the role of the activated proteins in the apoptotic pathways leading to neuronal death has not been properly defined. Previous reports implicated a number of proteins, including apolipoprotein E, cytoplasmic phospholipase A2, prostaglandin and calpain with anti-PrP antibody-mediated 'apoptosis', however, these proteins are also known to play an important role in allergy. In this study, we investigated whether cross-linking PrP^C with anti-PrP antibodies stimulates a neuronal allergenic response.

Methods

In

SUBMITTER: Adhikari UK 

PROVIDER: S-EPMC8361482 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature