Screening of Glypican-6 Expression in Benign, Primary and Metastatic Colon Cancers.

ABSTRACT:

Background

The development of colon cancer has been described as a multistep process of carcinogenesis. Understanding molecular and cellular changes underlying this process is required to determine potential biomarkers and therapeutic targets in colon cancers. Several molecular entities, including glypicans, are implicated in cancer development. Among these is glypican-6, which is overexpressed in a limited number of cancers. This study aims to characterise the glypican-6 expression in different types of colon cancer.

Methods

Immunohistochemistry was used to characterise glypican-6 expression in a panel of archived formalin-fixed, paraffin-embedded colon tissue types. These types included 39 normal colon tissues, 10 colon tubular adenomas, 60 colon adenocarcinomas without me

SUBMITTER: Al-Saraireh YM 

PROVIDER: S-EPMC8361513 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature