Disturbed microbial ecology in Alzheimer's disease: evidence from the gut microbiota and fecal metabolome.

ABSTRACT:

Background

Gut microbiota (GMB) alteration has been reported to influence the Alzheimer's disease (AD) pathogenesis through immune, endocrine, and metabolic pathways. This study aims to investigate metabolic output of the dysbiosis of GMB in AD pathogenesis. In this study, the fecal microbiota and metabolome from 21 AD participants and 44 cognitively normal control participants were measured. Untargeted GMB taxa was analyzed through 16S ribosomal RNA gene profiling based on next-generation sequencing and fecal metabolites were quantified by using ultrahigh performance liquid chromatography-mass spectrometry (UPLC-MS).

Results

Our analysis revealed that AD was characterized by 15 altered gut bacterial genera, of which 46.7% (7/15 general) was significantly associated with a s

SUBMITTER: Xi J 

PROVIDER: S-EPMC8361629 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature