Precision treatment exploration of breast cancer based on heterogeneity analysis of lncRNAs at the single-cell level.

ABSTRACT:

Background

Breast cancer (BC) is a complex disease with high heterogeneity, which often leads to great differences in treatment results. Current common molecular typing method is PAM50, which shows positive results for precision medicine; however, room for improvement still remains because of the different prognoses of subtypes. Therefore, in this article, we used lncRNAs, which are more tissue-specific and developmental stage-specific than other RNAs, as typing markers and combined single-cell expression profiles to retype BC, to provide a new method for BC classification and explore new precise therapeutic strategies based on this method.

Methods

Based on lncRNA expression profiles of 317 single cells from 11 BC patients, SC3 was used to retype BC, and differential express

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8361656 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature