Targeted sequencing reveals candidate causal variants for dairy bull subfertility.

ABSTRACT: Bull fertility is a key factor for successful reproductive performance in dairy cattle. Since the semen from a single bull can be used to inseminate hundreds of cows, one subfertile bull could have a major impact on herd reproductive efficiency. We have previously identified five genomic regions, located on BTA8 (72.2 Mb), BTA9 (43.7 Mb), BTA13 (60.2 Mb), BTA17 (63.3 Mb), and BTA27 (34.7 Mb), that show large dominance effects on bull fertility. Each of these regions explained about 5-8% of the observed differences in sire conception rate between Holstein bulls. Here, we aimed to identify candidate causal variants responsible for this variation using targeted sequencing (10 Mb per region). For each genomic region, two DNA pools were constructed from n≈20 high-fertility and n≈20 low-fertilit

SUBMITTER: Abdollahi-Arpanahi R 

PROVIDER: S-EPMC8361668 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature