Ontology highlight
ABSTRACT:
SUBMITTER: Tanokashira D
PROVIDER: S-EPMC8361845 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Tanokashira Daisuke D Wang Wei W Maruyama Megumi M Kuroiwa Chiemi C White Morris F MF Taguchi Akiko A
Biochemical and biophysical research communications 20210430
Type 2 diabetes mellitus (T2DM), characterized by hyperglycemia and insulin resistance, has been recognized as a risk factor for cognitive impairment and dementia, including Alzheimer's disease (AD). Insulin receptor substrate2 (IRS2) is a major component of the insulin/insulin-like growth factor-1 signaling pathway. Irs2 deletion leads to life-threatening T2DM, promoting premature death in male mice regardless of their genetic background. Here, we showed for the first time that young adult male ...[more]