Proteomic Bioprofiles and Mechanistic Pathways of Progression to Heart Failure.

ABSTRACT: Background Identifying the mechanistic pathways potentially associated with incident heart failure (HF) may provide a basis for novel preventive strategies. Methods and Results To identify proteomic biomarkers and the potential underlying mechanistic pathways that may be associated with incident HF defined as the first hospitalization for HF, a nested-matched case-control design was used with cases (incident HF) and controls (without HF) selected from 3 cohorts (>20 000 individuals). Controls were matched on cohort, follow-up time, age, and sex. Two independent sample sets (a discovery set with 286 cases and 591 controls and a replication set with 276 cases and 280 controls) were used to discover and replicate the findings. Two hundred fifty-two circulating proteins in the plasma were stud

SUBMITTER: Ferreira JP 

PROVIDER: S-EPMC8361846 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature