Impact of age and renal function on urine chemistry in patients with calcium oxalate kidney stones.

ABSTRACT: Nephrolithiasis is associated with an increased risk of chronic kidney disease, and its incidence varies with age. However, little is known on the combined impact of aging and declining renal function on urinary risk factors for calcium oxalate stone formation. A retrospective analysis was performed on 24-h urine collections from 993 calcium oxalate stone-forming patients. We first tested for interactions between age and creatinine clearance on various urinary determinants of calcium oxalate nephrolithiasis, and then examined their separate and combined effects in univariable and multivariable analyses adjusting for demographic and biochemical covariates. We identified significant interactions between age and creatinine clearance in predicting 24-h urine pH, calcium, and citrate. In view o

SUBMITTER: Tran TVM 

PROVIDER: S-EPMC8361852 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature