Multifunctional Heterometallic Ir^III -Au^I Probes as Promising Anticancer and Antiangiogenic Agents.

ABSTRACT: A new class of emissive cyclometallated Ir^III -Au^I complexes with a bis(diphenylphosphino) methanide bridging ligand was successfully synthesised from the diphosphino complex [Ir(N^C)₂ (dppm)]⁺ (1). The different gold ancillary ligand, a triphenylphosphine (2), a chloride (3) or a thiocytosine (4) did not reveal any significant effect on the photophysical properties, which are mainly due to metal-to-ligand charge-transfer (³ MLCT) transitions based on Ir^III . However, the Au^I fragment, along with the ancillary ligand, seemed crucial for the bioactivity in A549 lung carcinoma cells versus endothelial cells. Both cell types display variable sensitivities to the complexes (IC₅₀ =0.6-3.5 μM). The apoptotic

SUBMITTER: Redrado M 

PROVIDER: S-EPMC8361937 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature