Prostate cancer patient-derived organoids: detailed outcome from a prospective cohort of 81 clinical specimens.

ABSTRACT: Patient-derived organoids (PDOs) represent promising preclinical models in various tumor types. In the context of prostate cancer (PCa), however, their establishment has been hampered by poor success rates, which impedes their broad use for translational research applications. Along with the necessity to improve culture conditions, there is a need to identify factors influencing outcomes and to determine how to assess success versus failure in organoid generation. In the present study, we report our unbiased efforts to generate PDOs from a cohort of 81 PCa specimens with diverse pathological and clinical features. We comprehensively analyzed histological features of each enrolled sample (Gleason score, tumor content, proliferation index) and correlated them with organoid growth patterns. W

SUBMITTER: Servant R 

PROVIDER: S-EPMC8361965 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature