Easily Available, Amphiphilic Diiron Cyclopentadienyl Complexes Exhibit in Vitro Anticancer Activity in 2D and 3D Human Cancer Cells through Redox Modulation Triggered by CO Release.

ABSTRACT: A straightforward two-step procedure via single CO removal allows the conversion of commercial [Fe₂ Cp₂ (CO)₄ ] into a range of amphiphilic and robust ionic complexes based on a hybrid aminocarbyne/iminium ligand, [Fe₂ Cp₂ (CO)₃ {CN(R)(R')}]X (R, R'=alkyl or aryl; X=CF₃ SO₃ or BF₄ ), on up to multigram scales. Their physicochemical properties can be modulated by an appropriate choice of N-substituents and counteranion. Tested against a panel of human cancer cell lines, the complexes were shown to possess promising antiproliferative activity and to circumvent multidrug resistance. Interestingly, most derivatives also retained a significant cytotoxic activity against human cancer 3D cell cultur

SUBMITTER: Biancalana L 

PROVIDER: S-EPMC8362065 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature