Diagnostic accuracy of a point-of-care aMMP-8 test in the discrimination of periodontal health and disease.

ABSTRACT:

Aim

To assess the diagnostic utility of an oral rinse active matrix metalloproteinase-8 (aMMP-8) point-of-care test (POCT) for differentiating periodontal health, gingivitis, as well as different stages and grades of periodontitis.

Materials & methods

The aMMP-8 index test was undertaken in 408 consecutive adults, followed by a full-mouth periodontal examination. The reference standard was the 2017 World Workshop classification of periodontal diseases. Sensitivity, specificity, and the area under the receiver operating characteristic curve (AUROC) were assessed.

Results

68.6% of the participants were diagnosed with periodontitis, including Stages I (15.9%), II (15.9%), III (29.7%) and IV (7.1%). A positive aMMP-8 POCT was associated with periodontitis after adjusting

SUBMITTER: Deng K 

PROVIDER: S-EPMC8362205 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature