Ontology highlight
ABSTRACT:
SUBMITTER: Nitta T
PROVIDER: S-EPMC8362222 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Nitta Takeshi T Ota Ayami A Iguchi Takahiro T Muro Ryunosuke R Takayanagi Hiroshi H
Immunological reviews 20210606 1
Fibroblasts have recently attracted attention as a key stromal component that controls the immune responses in lymphoid tissues. The thymus has a unique microenvironment comprised of a variety of stromal cells, including fibroblasts and thymic epithelial cells (TECs), the latter of which is known to be important for T cell development because of their ability to express self-antigens. Thymic fibroblasts contribute to thymus organogenesis during embryogenesis and form the capsule and medullary re ...[more]