Investigating the correlation of muscle function tests and sarcomere organization in C. elegans.

ABSTRACT:

Background

Caenorhabditis elegans has been widely used as a model to study muscle structure and function. Its body wall muscle is functionally and structurally similar to vertebrate skeletal muscle with conserved molecular pathways contributing to sarcomere structure, and muscle function. However, a systematic investigation of the relationship between muscle force and sarcomere organization is lacking. Here, we investigate the contribution of various sarcomere proteins and membrane attachment components to muscle structure and function to introduce C. elegans as a model organism to study the genetic basis of muscle strength.

Methods

We employ two recently developed assays that involve exertion of muscle forces to investigate the correlation of muscle function to sarcomere or

SUBMITTER: Lesanpezeshki L 

PROVIDER: S-EPMC8362255 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature