Effects of dexmedetomidine on subthalamic local field potentials in Parkinson's disease.

ABSTRACT:

Background

Dexmedetomidine is frequently used for sedation during deep brain stimulator implantation in patients with Parkinson's disease, but its effect on subthalamic nucleus activity is not well known. The aim of this study was to quantify the effect of increasing doses of dexmedetomidine in this population.

Methods

Controlled clinical trial assessing changes in subthalamic activity with increasing doses of dexmedetomidine (from 0.2 to 0.6 μg kg^-1 h^-1) in a non-operating theatre setting. We recorded local field potentials in 12 patients with Parkinson's disease with bilateral deep brain stimulators (24 nuclei) and compared basal activity in the nuclei of each patient and activity recorded with different doses. Plasma levels of dexmedetomidine were ob

SUBMITTER: Martinez-Simon A 

PROVIDER: S-EPMC8362272 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature