Whole-brain morphological alterations associated with trigeminal neuralgia.

ABSTRACT:

Background

Novel neuroimaging strategies have the potential to offer new insights into the mechanistic basis for trigeminal neuralgia (TN). The present study aims to conduct whole-brain morphometry analyses of TN patients and to assess the value of group-level neocortical and subcortical structural patterns as tools for diagnostic biomarker exploration.

Methods

Cortical thickness, surface area, and myelin levels in the neocortex were measured via magnetic resonance imaging (MRI). The radial distance and the Jacobian determinant of the subcortex in 43 TN patients and 43 matched controls were compared. Pattern learning algorithms were employed to establish the utility of group-level MRI findings as tools for predicting TN. An additional 40 control patients with hemifacial spas

SUBMITTER: Mo J 

PROVIDER: S-EPMC8362283 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature