N⁶-Methyladenosine Regulators and Related LncRNAs Are Potential to be Prognostic Markers for Uveal Melanoma and Indicators of Tumor Microenvironment Remodeling.

ABSTRACT: Uveal melanoma (UM) is one of the most common malignant intraocular tumors in adults. Few studies have investigated the effect of N⁶-methyladenosine (m⁶A) RNA methylation regulators and related long noncoding RNAs (lncRNAs) on the tumor microenvironment (TME) and survival time of patients with UM. Based on the transcriptome and clinical data from The Cancer Genome Atlas, we systematically identified m⁶A regulators. Then, we constructed an m⁶A regulators-based signature to predict the prognostic risk using univariate and LASSO Cox analyses. The signature was then validated by performing Kaplan-Meier, and receiver operating characteristic analyses. Through the correlation analysis, m⁶A regulators-related lncRNAs were identified, and they

SUBMITTER: Liu Z 

PROVIDER: S-EPMC8362329 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature