Probiotics for the prevention of antibiotic-associated diarrhoea: a systematic review and meta-analysis.

ABSTRACT:

Objective

To evaluate existing evidence for the use of probiotics in preventing antibiotic-associated diarrhoea (AAD) in adults.

Design

Systematic review and meta-analysis of randomised controlled trials (RCTs).

Data sources

We performed a literature search of the electronic databases CINAHL Plus, EMBASE, MEDLINE (Ovid) and Web of Science from database inception to May 2021 as well as hand searching of trial registries and reference lists of related reviews.

Study selection

Two reviewers identified whether RCTs met the following inclusion criteria: adult population to whom antibiotics were administered; a probiotic intervention; a placebo, alternative dose, alternative probiotic strain or no treatment control; and incidence of AAD as the outcome.

Data extrac

SUBMITTER: Goodman C 

PROVIDER: S-EPMC8362734 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature