Lung Transplant Improves Survival and Quality of Life Regardless of Telomere Dysfunction.

ABSTRACT: Introduction: Fibrotic interstitial lung diseases (ILDs) are the first indication for lung transplantation (LT). Telomere dysfunction has been associated with poor post-transplant outcomes. The aim of the study was to evaluate the morbi-mortality and quality of life in fibrotic ILDs after lung transplant depending on telomere biology. Methods: Fibrotic ILD patients that underwent lung transplant were allocated to two arms; with or without telomere dysfunction at diagnosis based on the telomere length and telomerase related gene mutations revealed by whole-exome sequencing. Post-transplant evaluation included: (1) short and long-term mortality and complications and (2) quality of life. Results: Fifty-five percent of patients that underwent LT carried rare coding mutatio

SUBMITTER: Planas-Cerezales L 

PROVIDER: S-EPMC8362799 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature