Significance of serum CA125 level in surgically resected cervical adenocarcinoma with adverse features.

ABSTRACT:

Objective

Unlike cervical squamous cell carcinoma, there are no consensus criteria for serum tumor markers in cervical adenocarcinoma. This study aimed to identify the prognostic value of preoperative carbohydrate antigen 125 (CA125) levels in cervical adenocarcinoma patients with adverse pathologic features.

Methods

A total of 105 patients who underwent radical hysterectomy followed by adjuvant radiotherapy (RT) or concurrent chemoradiation therapy were included. Locoregional recurrence-free survival (LRFS), distant metastasis-free survival (DMFS), and overall survival (OS) were evaluated using the Cox proportional hazard regression model.

Results

Using a cutoff value of 50 U/mL, 83 and 22 patients had low- and high-CA125, respectively. Patients with high-CA125 had a

SUBMITTER: Kim N 

PROVIDER: S-EPMC8362813 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature