Local Anatomic Precursors to New-Onset Geographic Atrophy in Age-Related Macular Degeneration as Defined on OCT.

ABSTRACT:

Purpose

In macula-wide analyses, spectral-domain (SD) optical coherence tomography (OCT) features including drusen volume, hyperreflective foci, and OCT-reflective drusen substructures independently predict geographic atrophy (GA) onset secondary to age-related macular degeneration (AMD). We sought to identify SD OCT features in the location of new GA before its onset.

Design

Retrospective study.

Participants

Age-Related Eye Disease Study 2 Ancillary SD OCT Study participants.

Methods

We analyzed longitudinally captured SD OCT images and color photographs from 488 eyes of 488 participants with intermediate AMD at baseline. Sixty-two eyes with sufficient image quality demonstrated new-onset GA on color photographs during study years 2 through 7. The area of new-

SUBMITTER: Pasricha MV 

PROVIDER: S-EPMC8362836 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature