Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target.

ABSTRACT: Ca²⁺ is a fundamental second messenger in all cell types and is required for numerous essential cellular functions, including cardiac and skeletal muscle contraction. The intracellular concentration of free Ca²⁺ ([Ca²⁺]) is regulated primarily by ion channels, pumps (ATPases), exchangers and Ca²⁺-binding proteins. Defective regulation of [Ca²⁺] is found in a diverse spectrum of pathological states that affect all the major organs. In the heart, abnormalities in the regulation of cytosolic and mitochondrial [Ca²⁺] occur in heart failure (HF) and atrial fibrillation (AF), two common forms of heart disease and leading contributors to morbidity and mortality. In this Review, we focus on the mechanisms that regulate ryanodine rec

SUBMITTER: Dridi H 

PROVIDER: S-EPMC8362847 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature