Discerning Patterns and Quality of Neoadjuvant Chemotherapy Use Among Patients with Muscle-invasive Bladder Cancer.

ABSTRACT:

Background

Neoadjuvant chemotherapy is underutilized in bladder cancer patients who undergo radical cystectomy. However, the quality of regimens used in this setting remains largely unknown.

Objective

To determine utilization treatment patterns and survival outcomes according to regimens administered.

Design, setting, and patients

We used the Surveillance, Epidemiology and End Results (SEER)-Medicare linked database to identify patients diagnosed with clinical stage TII-IV bladder cancer from January 1, 2001 to December 31, 2011.

Outcome measurements and statistical analysis

Temporal trends were assessed using the Cochran-Armitage test. Multivariable logistic regression models were used to identify predictors for neoadjuvant chemotherapy use. Cox proportional h

SUBMITTER: Huo J 

PROVIDER: S-EPMC8362849 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature