A PGE₂-MEF2A axis enables context-dependent control of inflammatory gene expression.

ABSTRACT: Tight control of inflammatory gene expression by antagonistic environmental cues is key to ensure immune protection while preventing tissue damage. Prostaglandin E₂ (PGE₂) modulates macrophage activation during homeostasis and disease, but the underlying mechanisms remain incompletely characterized. Here we dissected the genomic properties of lipopolysaccharide (LPS)-induced genes whose expression is antagonized by PGE₂. The latter molecule targeted a set of inflammatory gene enhancers that, already in unstimulated macrophages, displayed poorly permissive chromatin organization and were marked by the transcription factor myocyte enhancer factor 2A (MEF2A). Deletion of MEF2A phenocopied PGE₂ treatment and abolished type I interferon (IFN I) induct

SUBMITTER: Cilenti F 

PROVIDER: S-EPMC8362890 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature