Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts.

ABSTRACT: Tumor-associated tertiary lymphoid structures (TA-TLS) are associated with enhanced patient survival and responsiveness to cancer therapies, but the mechanisms underlying their development are unknown. We show here that TA-TLS development in murine melanoma is orchestrated by cancer-associated fibroblasts (CAF) with characteristics of lymphoid tissue organizer cells that are induced by tumor necrosis factor receptor signaling. CAF organization into reticular networks is mediated by CD8 T cells, while CAF accumulation and TA-TLS expansion depend on CXCL13-mediated recruitment of B cells expressing lymphotoxin-α₁β₂. Some of these elements are also overrepresented in human TA-TLS. Additionally, we demonstrate that immunotherapy induces more and larger TA-TLS that are mor

SUBMITTER: Rodriguez AB 

PROVIDER: S-EPMC8362934 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature