Are neighbourhoods of tuberculosis cases a high-risk population for active intervention? A protocol for tuberculosis active case finding.

ABSTRACT:

Background

Indonesia has the second largest tuberculosis (TB) burden globally. Attempts to scale-up TB control efforts have focused on TB households. However, in most high burden settings, considerable Mycobacterium tuberculosis (Mtb) transmission occurs outside TB households. A better understanding of transmission dynamics in an urban setting in Indonesia will be crucial for the TB Control Program in scaling up efforts towards elimination of TB in a more targeted way. Therefore, the study aims to measure TB prevalence and incidence in household contacts and neighbourhoods in the vicinity of known TB cases and to assess their genomic and epidemiological relatedness.

Methods and analysis

Individuals (~1000) living in the same household as a case diagnosed with pulmonary TB (n

SUBMITTER: Alisjahbana B 

PROVIDER: S-EPMC8362935 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature