Characterization of local and peripheral immune system in pregnant and nonpregnant ewes.

ABSTRACT: Modulation of the immune system is known to be important for successful pregnancy but how immune function might differ between the lymph nodes draining the reproductive tract and peripheral lymph nodes is not well understood. Additionally, if immune system changes in response to the presence of an embryo during early pregnancy, and if this response differs in local versus peripheral immune tissue, has not been well characterized. To address these questions, we examined expression of genes important for immune function using NanoString technology in the ampulla and isthmus of the oviduct, endometrium, lymph nodes draining the reproductive tract (lumbo-aortic and medial iliac) as well as a peripheral lymph node (axillary), the spleen, and circulating immune cells from ewes on day 5 of the es

SUBMITTER: Quirke LD 

PROVIDER: S-EPMC8363041 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature