Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC8363062 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Liu Yuhao Y Zhao Ying Y Shukha Yousef Y Lu Haocheng H Wang Lu L Liu Zhipeng Z Liu Cai C Zhao Yang Y Wang Huilun H Zhao Guizhen G Liang Wenying W Fan Yanbo Y Chang Lin L Yurdagul Arif A Pattillo Christopher B CB Orr A Wayne AW Aviram Michael M Wen Bo B Garcia-Barrio Minerva T MT Zhang Jifeng J Liu Wanqing W Sun Duxin D Hayek Tony T Chen Y Eugene YE Rom Oren O
Cell reports 20210701 4
Dysregulated glycine metabolism is emerging as a common denominator in cardiometabolic diseases, but its contribution to atherosclerosis remains unclear. In this study, we demonstrate impaired glycine-oxalate metabolism through alanine-glyoxylate aminotransferase (AGXT) in atherosclerosis. As found in patients with atherosclerosis, the glycine/oxalate ratio is decreased in atherosclerotic mice concomitant with suppression of AGXT. Agxt deletion in apolipoprotein E-deficient (Apoe<sup>-/-</sup>) ...[more]