SFRP2 induces a mesenchymal subtype transition by suppression of SOX2 in glioblastoma.

ABSTRACT: Intratumoral heterogeneity is a characteristic of glioblastomas that contain an intermixture of cell populations displaying different glioblastoma subtype gene expression signatures. Proportions of these populations change during tumor evolution, but the occurrence and regulation of glioblastoma subtype transition is not well described. To identify regulators of glioblastoma subtypes we utilized a combination of in vitro experiments and in silico analyses, using experimentally generated as well as publicly available data. Through this combined approach SOX2 was identified to confer a proneural glioblastoma subtype gene expression signature. SFRP2 was subsequently identified as a SOX2-antagonist, able to induce a mesenchymal glioblastoma subtype signature. A subset of patient glioblastoma s

SUBMITTER: Guo M 

PROVIDER: S-EPMC8363098 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature