Clinical Features of Group A Streptococcus in Children With Pharyngitis: Carriers versus Acute Infection.

ABSTRACT:

Background

Among children with pharyngitis who test positive for group A Streptococcus (GAS), 10%-25% are GAS carriers. Current laboratory methods cannot distinguish acute infection from colonization.

Methods

We examined 2 separate longitudinal studies of children with symptomatic pharyngitis associated with a positive GAS throat culture (illness culture). In cohort 1, children presented with pharyngitis symptoms to a clinician, then had follow-up cultures at regular intervals. In cohort 2, throat cultures were performed at regular intervals and with pharyngitis symptoms. Illness cultures were categorized as acute infection or carrier based on follow-up culture results. In cohort 2, carriers were further categorized as a GAS carrier with a new emm-type or a GAS carrier with

SUBMITTER: Rick AM 

PROVIDER: S-EPMC8363186 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature