Sleep, Noninvasive Brain Stimulation, and the Aging Brain: Challenges and Opportunities.

ABSTRACT: As we age, sleep patterns undergo severe modifications of their micro and macrostructure, with an overall lighter and more fragmented sleep structure. In general, interventions targeting sleep represent an excellent opportunity not only to maintain life quality in the healthy aging population, but also to enhance cognitive performance and, when pathology arises, to potentially prevent/slow down conversion from e.g. Mild Cognitive Impairment (MCI) to Alzheimer's Disease (AD). Sleep abnormalities are, in fact, one of the earliest recognizable biomarkers of dementia, being also partially responsible for a cascade of cortical events that worsen dementia pathophysiology, including impaired clearance systems leading to build-up of extracellular amyloid-β (Aβ) peptide and intracellular hyperphosp

SUBMITTER: Romanella SM 

PROVIDER: S-EPMC8363192 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature