Unbiased Screening Identifies Functional Differences in NK Cells After Early Life Psychosocial Stress.

ABSTRACT: Early Life Adversity (ELA) is closely associated with the risk for developing diseases later in life, such as autoimmune diseases, type-2 diabetes and cardiovascular diseases. In humans, early parental separation, physical and sexual abuse or low social-economic status during childhood are known to have great impact on brain development, in the hormonal system and immune responses. Maternal deprivation (MD) is the closest animal model available to the human situation. This paradigm induces long lasting behavioral effects, causes changes in the HPA axis and affects the immune system. However, the mechanisms underlying changes in the immune response after ELA are still not fully understood. In this study we investigated how ELA changes the immune system, through an unbiased analysis, viSNE,

SUBMITTER: Fernandes SB 

PROVIDER: S-EPMC8363253 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature