Calcium phosphate microcrystals in the renal tubular fluid accelerate chronic kidney disease progression.

ABSTRACT: The Western pattern diet is rich not only in fat and calories but also in phosphate. The negative effects of excessive fat and calorie intake on health are widely known, but the potential harms of excessive phosphate intake are poorly recognized. Here, we show the mechanism by which dietary phosphate damages the kidney. When phosphate intake was excessive relative to the number of functioning nephrons, circulating levels of FGF23, a hormone that increases the excretion of phosphate per nephron, were increased to maintain phosphate homeostasis. FGF23 suppressed phosphate reabsorption in renal tubules and thus raised the phosphate concentration in the tubule fluid. Once it exceeded a threshold, microscopic particles containing calcium phosphate crystals appeared in the tubule lumen, which da

SUBMITTER: Shiizaki K 

PROVIDER: S-EPMC8363285 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature