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The Promise of Personalized TCR-Based Cellular Immunotherapy for Cancer Patients.


ABSTRACT: Mutation-derived neoantigens are now established as attractive targets for cancer immunotherapy. The field of adoptive T cell transfer (ACT) therapy was significantly reshaped by tumor neoantigens and is now moving towards the genetic engineering of T cells with neoantigen-specific T cell receptors (TCRs). Yet, the identification of neoantigen-reactive TCRs remains challenging and the process needs to be adapted to clinical timelines. In addition, the state of recipient T cells for TCR transduction is critical and can affect TCR-ACT efficacy. Here we provide an overview of the main strategies for TCR-engineering, describe the selection and expansion of optimal carrier cells for TCR-ACT and discuss the next-generation methods for rapid identification of relevant TCR candidates for gene transfer therapy.

SUBMITTER: Arnaud M 

PROVIDER: S-EPMC8363295 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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The Promise of Personalized TCR-Based Cellular Immunotherapy for Cancer Patients.

Arnaud Marion M   Bobisse Sara S   Chiffelle Johanna J   Harari Alexandre A  

Frontiers in immunology 20210730


Mutation-derived neoantigens are now established as attractive targets for cancer immunotherapy. The field of adoptive T cell transfer (ACT) therapy was significantly reshaped by tumor neoantigens and is now moving towards the genetic engineering of T cells with neoantigen-specific T cell receptors (TCRs). Yet, the identification of neoantigen-reactive TCRs remains challenging and the process needs to be adapted to clinical timelines. In addition, the state of recipient T cells for TCR transduct  ...[more]

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