Ontology highlight
ABSTRACT:
SUBMITTER: Arnaud M
PROVIDER: S-EPMC8363295 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Arnaud Marion M Bobisse Sara S Chiffelle Johanna J Harari Alexandre A
Frontiers in immunology 20210730
Mutation-derived neoantigens are now established as attractive targets for cancer immunotherapy. The field of adoptive T cell transfer (ACT) therapy was significantly reshaped by tumor neoantigens and is now moving towards the genetic engineering of T cells with neoantigen-specific T cell receptors (TCRs). Yet, the identification of neoantigen-reactive TCRs remains challenging and the process needs to be adapted to clinical timelines. In addition, the state of recipient T cells for TCR transduct ...[more]